Synthesis of biphenyl-based arsine ligands by microwave assisted Suzuki-Miyaura coupling and their applications

GISELA J. QUINTEROS; SANDRA E. MARTÍN

Blucher Chemistry Proceedings

Editora Blucher

Año: 2011 vol. 1 p. 162 - 162

2318-4043

ynthesis of biphenyl-based arsine ligands by microwaveassisted Suzuki-Miyaura coupling and their applications Gisela J. Quinteros, Sandra E. Martín* INFIQC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000-Córdoba, Argentina *e-mail martins@fcq.unc.edu.ar Keywords: arsine ligands, Suzuki-Miyaura, microwave INTRODUCTION Over the past few years, there has been a growing interest in the synthesis and application of biphenylbased monophosphine ligands.1 Although tertiary phosphines constitute the group of ligands most widely used in metal-catalyzed reactions, arsines have been shown to be excellent ligands and there are several examples where arsine complexes give more active or selective catalysts than phosphines. We have developed a versatile methodology that allow for C-As bond formation through a Pdcatalyzed arsination with stannane n-Bu3SnAsPh2. 2 By this methodology we carried out the synthesis of a novel biphenylarsine ligand bi