Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks

MARÍA S. GASTÓN; MARIANA P. CID; ANA M. VÁZQUEZ; MARÍA F. DECARLINI; GABRIELA I. DEMMEL; LAURA ISABEL ROSSI; MARIO L. AIMAR; NANCY A. SALVATIERRA

PHARMACEUTICAL BIOLOGY

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2016

1388-0209

BSTRACTContext Coriandrum sativum L. (Apiaceae) (coriander) is an herb grown throughout the world as a culinary, medicinal or essential crop. In traditional medicine, it is used for the relief of anxiety and insomnia. Systemic hydro-alcoholic and aqueous extract from aerial parts and seeds had anxiolytic and sedative action in rodents, but little is known about its central effect in chicks.Objective To study the effects of intracerebroventricular administration of essential oil fromcoriander seeds and its major component linalool on locomotor activity and emotionality ofneonatal chicks.Materials and methods The chemical composition of coriander essential oil was determined by a gas-chromatographic analysis (480% linalool). Behavioural effects of central administration of coriander oil and linalool (both at doses of 0.86, 8.6 and 86 mg/chick) versus saline and a sedative diazepam dose (17.5 mg/chick, standard drug) in an open field test for 10 min were obs