Artículos
Título:
Evidence for the Involvement of Tiam1 in Axon Formation
Autor/es:
P. KUNDA; G. PAGLINI; S. QUIROGA; K. KOSIK; A. CÁCERES
Revista:
The Journal of Neurosciences
Referencias:
Año: 2001 vol. 21 p. 2361 - 2361
Resumen:
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In cultured neurons, axon formation is preceded by the appearance
in one of the multiple neurites of a large growth cone
containing a labile actin network and abundant dynamic microtubules.
The invasion-inducing T-lymphoma and metastasis 1
(Tiam1) protein that functions as a guanosine nucleotide exchange
factor for Rac1 localizes to this neurite and its growth
cone, where it associates with microtubules. Neurons overexpressing
Tiam1 extend several axon-like neurites, whereas suppression
of Tiam1 prevents axon formation, with most of the
cells failing to undergo changes in growth cone size and in
cytoskeletal organization typical of prospective axons. Cytochalasin
D reverts this effect leading to mult