Expression and distribution of IGF-1 receptors containig a novel beta subunit variant (betagc) enriched in the growth cone of developing neurons

F. MASCOTTI; A. CÁCERES; K.H. PFENNINGER; S. QUIROGA

The Journal of Neurosciences

Año: 1997 vol. 17 p. 1447 - 1447

font face="MathematicalPi-One" size="1"> bgc is a b-subunit variant of the insulin-like growth factor-1 (IGF-1) receptor highly enriched in growth cone membranes prepared by subcellular fractionation of fetal rat brain (Quiroga et al., 1995). The present study is focused on the expression and on the cellular and subcellular distribution of bgc in developing neurons and differentiating PC12 cells. In the developing cerebral cortex and, at least at early stages, in cultured primary neurons,