IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity

SOSA L., DUPRAZ S., LAURINO .L, BOLLATI F., BISBAL M., CACERES A., PFENNINGER K.H., QUIROGA S

NATURE NEUROSCIENCE

Año: 2006 vol. 9 p. 993 - 993

h1 style="MARGIN: 0cm -0.05pt 0pt 0cm">ABSTRACT How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and a siRNA targeting the IGF-1 receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the PI3k-Cdc42 pathway by the IGF-1 receptor, but not by the receptors TrkA or B.