BOCCO JOSE LUIS
Artículos
Título:
Heterogeneous Vancomycin-Intermediate susceptibility in a Community-Associated Methicillin-Resistant Staphylococcus aureus epidemic clone belonging to the ST5-IV Genotype in a case of Infective Endocarditis in Argentina
Autor/es:
SOLA C; LAMBERGHINI RO; CIARLANTINI M; EGEA AL; GONZALEZ P; DIAZ EG; HUERTA V; GONZALEZ J; CORSO A; VILARO M; PETITI JP; TORRES A; VINDEL A; BOCCO J.L.
Revista:
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
Editorial:
BIOMED CENTRAL
Referencias:
Lugar: London; Año: 2011 vol. 10 p. 1 - 1
ISSN:
1476-0711
Resumen:
ackground: Community-Associated Methicillin Resistant Staphylococcus aureus (CA-MRSA) has traditionally been related to skin and soft tissue infections in healthy young patients. However, it has now emerged as responsible for severe infections worldwide, for which vancomycin is one of the mainstays of treatment. Infective endocarditis (IE) due to CA-MRSA with heterogeneous vancomycin-intermediate susceptibility-(h-VISA) has been recently reported, associated to an epidemic USA 300 CA-MRSA clone. Case Presentation: We describe the occurrence of h-VISA phenotype in a case of IE caused by a strain belonging to an epidemic CA-MRSA clone, distinct from USA300, for the first time in Argentina. The isolate h-VISA (SaB2) was recovered from a patient with persistent bacteraemia after a 7-day therapy with vancomycin, which evolved to fatal case of IE complicated with brain abscesses. The initial isolate-(SaB1) was fully vancomycin susceptible (VSSA). Although MRSA SaB2 was vancomycin