New patterns of methicillin-resistant Staphylococcus aureus (MRSA) clones, community-associated MRSA genotypes behave like healthcare-associated MRSA genotypes within hospitals, Argentina.

EGEA A.L.; GAGETTI P.; LAMBERGHINI R.O.; FACCONE D.; LUCERO C.; GALAS M.; VINDEL A.; TOSORONI D.; MRSA CORDOBA STUDY GROUP; BOCCO J.L.; CORSO A.; SOLA C.

ELSEVIER GMBH

Lugar: Jena; Año: 2014

ethicillin-resistant Staphylococcus aureus (MRSA) burden is increasingly worldwide in hospitals [healthcare-associated (HA)-MRSA] and in communities [community-associated (CA)-MRSA]. However, the impact of CA-MRSA within hospitals remains limited, particularly in Latin America. A nationally representative survey of S. aureus infections was performed in Argentina by analyzing 591 clinical isolates from 66 hospitals in a prospective-cross-sectional-multicenter-study (Nov-2009). This study involved healthcare-onset infections-(HAHO, >48 hospitalization hours) and community-onset (CO) infections [including both, infections (HACO) in patients with healthcare-associated risk-factors (HRFs) and infections in those without HRFs, (CACO)]. MRSA strains were genetically typed as CA-MRSAG and HA-MRSAG genotypes (G) or strain type, by SCCmec- and spa-typing, PFGE, MLST and virulence genes profile by PCR. Considering all isolates, 63% were from CO- infections and 55% were MRSA [39% CA-MRSAG and 16%