Silencing of the transcription factor KLF6 by siRNA leads to cell cycle arrest and sensitizes cells to apoptosis induced by DNA damage.

D?ASTOLFO, DIEGO; GEHRAU, RICARDO; BOCCO JOSE LUIS; KORISTCHONER, NICOLAS

Nature Publishing Group

Lugar: Hampshire - UK; Año: 2008 vol. 15 p. 613 - 613

p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal">Kruppel-like factor 6 (KLF6) belongs to a large family of mammalian Sp1-like/KLF transcription factors that play critical roles in regulating key cellular functions ranging from differentiation to proliferation and apoptosis. KLF6 is an evolutionarily conserved and ubiquitously expressed protein that was originally identified as an activator of pregnancy specific genes. Initial evidence has implicated KLF6 as a tumor suppressor gene, which was found to be the subject of frequent somatic mutations in certain carcinomas. Given its potential role as a tumor suppressor gene, much effort has gone into determining altered KLF6 genotypes. Results have been rather controversial since a number of studies established that genetic alterations of KLF6 were infrequently observed in distinct types of human cancers (see Lievre