Differential Expression of the KLF6 Tumor Suppressor Gene Upon Cell Damaging Treatments in Cancer Cells.

GEHRAU RC; D'ASTOLFO DS; ANDREOLI V; BOCCO JL* (CORRESPONDIG AUTHOR); KORITSCHONER NP

ELSEVIER SCIENCE BV

Año: 2010 vol. 707 p. 15 - 15

p style="TEXT-INDENT: 7.1pt; MARGIN: 0cm 0cm 0pt">The mammalian Krüppel-like factor 6 (KLF6) is involved in critical roles such as growth-related signal transduction, cell proliferation and differentiation, development, apoptosis and angiogenesis. Also, KLF6 appears to be an emerging key factor during cancer development and progression. Its expression is thoroughly regulated by several cell-damaging stimuli. DNA damaging agents at lethal concentrations induce a p53-independent down-regulation of the klf6 gene. To investigate the impact of external stimuli on human klf6 gene expression, its mRNA level was analyzed using a cancer cell line profiling array system, consisting in an assortment of immobilized cDNAs from multiple cell lines treated with several cell-damaging agents at growth inhibitory concentrations (IC50).