GH3B6 pituitary adenoma cell growth is promoted by the activation of PKCƒÑ and PKCƒÕ via ERK 1/2-dependent pathway

PETITI J.P.; GUTIÉRREZ S.; DE PAUL A.L.; ANDREOLI V.; PALMERI C.M.; SOSA LDEL V.; BOCCO J.L.; TORRES AI.

KARGER

Lugar: Basel; Año: 2010 vol. 26 p. 135 - 135

p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt" class="MsoNormal">BACKGROUND: In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated. METHODS: The GH3B6 cell proliferation was estimated by BrdU incorporation and the cell cycle progression by flow cytometric cell cycle ana