BOCCO JOSE LUIS
Congresos y reuniones científicas
Título:
KLF6 Sucbellular Distribution as a Marker of Tumor Aggressiveness in Human Colon Adenocarcinoma.
Autor/es:
GRUPE V.; SABATINO M.E.; CORDERO V.; CABALIER E.; LUCCA A.; CORTIÑAS E.; MONTEVERDI L.; BOCCO J.L.
Lugar:
Córdoba
Reunión:
Congreso; 52° Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular - SAIB 2016.; 2016
Institución organizadora:
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Resumen:
Colorectal cancer (CRC) is the second most frequent cancer type in our country, representing the 12% of total cancer deaths. However, it is one of the most preventable tumors due to its slow progression and early detection increases complete remission chances up to 90%. Unfortunately, useful molecular biomarkers for CRC early detection are not available. Krüppel-like factor 6 (KLF6) is a tumor suppressor related with several types of cancers though its function in CRC is not deeply known. Our aim was to investigate whether KLF6 expression could be associated with CRC pathogenesis. We establish the frequency of KLF6 suCBellular expression in 37 human CRC by immunohistochemistry and we found that 83% of the cases showed a generalized KLF6 cytoplasmic expression. However, nuclear localization revealed a more gradual pattern, even showing null expression. We correlated these data with CRC pathology grades and we found a positive correlation between KLF6 nuclear expression and tumor stage (r= 0.36) and a negative correlation with tissue differentiation (r= -0.33). In addition, null nuclear expression correlated with low proliferation index (p<0.05). In summary, increased KLF6 nuclear localization in CCR could be related with a more advanced and an aggressive tumor behavior, suggesting that KLF6 suCBellular expression might be a plausible marker for early diagnosis and prognosis of CCR.