Community-Associated Methicillin Resistant S. aureus Hospital-Acquired, Argentina.

BARCUDI D.; EGEA A.L.; MRSA CORDOBA STUDY GROUP; GAGETTI P.; FACCONE D.; CORSO A.; BOCCO J.L.; SOLA C.

Córdoba

Congreso; 52° Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular - SAIB 2016.; 2016

Sociedad Argentina de Investigación en Bioquímica y Biología Molecular

Methicillin-resistantS. aureus(MRSA) burden is increasingly worldwide in hospitals [healthcare-associated (HA)-MRSA] and in the communities [community-associated (CA)-MRSA]. The definition of healthcare-onset CA-MRSA infection is based on time from hospital admission to culture, but the knowledge about the actual time and origin of MRSA acquisition is limited. We aimed to determine prevalence on admission, acquisition rates and molecular epidemiology of MRSA in Córdoba hospitals, Argentina. A prospective multicenter study was conducted (October-November 2014) in 8 Córdoba hospitals. Colonization samples were obtained from nasal, pharyngeal and skin swabs from patients at hospital admission and discharge. MRSA were studied by SCC mecand spa-typing, PVL, PFGE and MLST. A total of 1419 patients were screened, 58 (4,1%) were colonized by MRSA [44 (3%) CA-MRSA and 8 (1%) HA-MRSA], this proportion differed significantly between pediatric (6%) and adult (3%) patients (p<0.0001). The most frequent genotypes were associated with PVL+CAMRSA epidemic clones: ST5-IVa-t311 (27%) and ST30-IVc-t019(19%) followed by HAMRSA clones C-ST100-IVNv (15%) and A-ST5-I (7%). Overall MRSA acquisition rate was 2.3/1000 patient days at risk and all these MRSA were CA-MRSA genotypes. These results demonstrate the acquisition and transmission of CA-MRSA strains within hospitals in our country.