BOCCO JOSE LUIS
Congresos y reuniones científicas
Título:
KLF6 IS REQUIRED FOR OXIDATIVE AND ONCOGENE-INDUCED CELLULAR SENESCENCE
Autor/es:
SABATINO M.E.; CASTELLARO A.; RACCA A.; CARBAJOSA S.; PANSA M. F.; SORIA G.; BOCCO J.L.
Lugar:
Salta
Reunión:
Congreso; Joint LV Annual SAIB Meeting and XIV PABMB Congress; 2019
Institución organizadora:
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Resumen:
The KLF6 protein is a transcription factor involved in the regulation of several cellular processes during the cell cycle. Regarding its role in tumorigenesis, KLF6 is reputed as a tumor suppressor since numerous reports demonstrate its frequent genomic loss or downregulation, implying a functional inactivation, in a broad range of human cancers. Previous work from our laboratory showed that the down-regulation of KLF6 expression in normal fibroblasts led to cellular transformation whereas its ectopic expression interfered with oncogenic transformation triggered by activated Ras, through a cell cycle arrest. We hypothesize that the growth suppressor activity of KLF6 may involve the induction of cellular senescence thereby preventing the proliferation of cells at risk of neoplastic transformation. Here, we determined the association of KLF6 upregulation in two different cellular senescence scenarios. We also observed that KLF6 silencing bypassed either oxidative or oncogene-induced senescence. Moreover, KLF6 expression per se was capable to trigger cellular senescence in both normal and tumoral contexts. Results presented in this work provide insights into a potential mechanism by which KLF6 may play a suppressing role of uncontrolled or damaged cell proliferation.