IQGAP1: a microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity

JAUSORO I; MESTRES I; REMEDI MM; SANCHEZ M; CACERES A

F HERNANDEZ

Lugar: Madrid; Año: 2012 vol. 27 p. 1385 - 1385

n this article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, including neurons, and capable of linking Rho-GTPase signaling with  cytosleletal elements and environmental cues. Interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density.