Neovascular retinopathies: etiology and models of study for searching new therapeutic targets

RIDANO MAGALI E; LUNA JD; LORENC VE; SUBIRADA CALDARONE PAULA; MARIA CONSTANZA PAZ;; VAGLIENTI MV; BARCELONA PF; MARIA CECILIA SANCHEZ

Anales AFA

Asociación Física Argentina

Lugar: Tandil; Año: 2018

0327-358X

he eye is an ideal model for the study of biochemical, molecular and cellular mechanisms related not only to vascular development and physiological remodeling but also to retinal neovascular disorders. Among them, neovascular retinopathies are the main causes of blindness. In these pathologies, the visual deficit has been caused in part by an imbalance in angiogenic factors generated by ischemia, which produce the neovessels formation and hemorrhages, with a partial or total reduction of vision. Vascular endothelial growth factor A (VEGF-A) is the most studied molecule that mediates retinal neovascularization induced by ischemia in ocular pathologies. The treatments for these retinopathies (photocoagulation, vitrectomy, intraocular injection of monoclonal antibodies) try to stop them but only in very specific cases they improve it, so the search for new therapeutic targets is a challenge at present. In this review, we will provide information about the current knowledge of the etiolog