Multitarget activities of Müller glial cells and low-density lipoprotein receptor-related protein 1 in proliferative retinopathies".

MARIA CECILIA SANCHEZ; GUSTAVO ALBERTO CHIABRANDO;

ASN Neuro

American Society for Neurochemistry

Año: 2022

1759-0914

üller glial cells (MGCs), the main glial component of the retina, play an active role in retinal homeostasis during development andpathological processes. They strongly monitor retinal environment and, in response to retinal imbalance, activate neuroprotectivemechanisms mainly characterized by the increase of glial fibrillary acidic protein (GFAP). Under these circumstances, if homeostasis is not reestablished, the retina can be severely injured and GFAP contributes to neuronal degeneration, as they occur inseveral proliferative retinopathies such as diabetic retinopathy, sickle cell retinopathy and retinopathy of prematurity. In addition,MGCs have an active participation in inflammatory responses releasing proinflammatory mediators and metalloproteinases to theextracellular space and vitreous cavity. MGCs are also involved in the retinal neovascularization and matrix extracellular remodeling during the proliferative stage of retinopathies. Interestingly, low-density lipoprotein recep