"Pregnancy Specific Glycoprotein 1a can activate dendritic cells to provide signals for Th17-, Th2- and Treg-cell polarization"

MARTINEZ F; KNUBEL C; SANCHEZ CECILIA; CERVI L; MOTRAN CC

EUROPEAN JOURNAL OF IMMUNOLOGY

Wiley

Año: 2012 vol. 42 p. 1573 - 1573

1521-4141

ecause of their plasticity and central role in orchestrating immunity and tolerance,DCs can respond to pregnancy-specific signals, thus promoting the appropriate immuneresponse in order to support pregnancy. Here, we show that pregnancy-specific glycoprotein (PSG1a), the major variant of PSG released into the circulation during pregnancy,targets DCs to differentiate into a subset with a unique phenotype and function. Thissemimature phenotype is able to secrete IL-6 and TGF-β. PSG1a also affected the maturationof DCs, preventing the up-regulation of some costimulatory molecules, and inducing thesecretion of TGF-β or IL-10 and the expression of programmed death ligand 1 (PD-L1)in response to TLR-9 or CD40 ligation. In addition, PSG1a-treated DCs promoted theenrichment of Th2-type cytokines, IL-17-producing cells, and Treg cells from CD4+ T cellsfrom DO11.10 Tg mice. Moreover, in vivo expression of PSG1a promoted the expansionof Ag-specific CD4+CD25+Foxp3+ Treg cells and IL-17-