MODELOS ANIMALES DE RETINOPATÍA DIABÉTICA: COMPRENSIÓN DE LA PATOGÉNESIS Y POTENCIAL UTILIZACIÓN EN EL DESARROLLO DE NUEVOS AGENTES TERAPÉUTICOS.

SUBIRADA CALDARONE PAULA; LORENC VE; SANCHEZ MC,

Bitacora digital

Facultad de Ciencias Quimicas

Año: 2013 vol. 1 p. 24 - 24

2344-9144

iabetic retinopathy (DR) is the most commonmicrovascular complications of diabetes and one of theleading causes of blindness worldwide. Several animalmodels have been generated by pharmacological induction,feeding a galactose diet and spontaneously by selectiveinbreeding or genetic modification. Among them, rodentshave been the most studied because of their shortgeneration time, and the inherited to hyperglycemia and / orobesity that affects certain strains. Particularly, mice haveshown to be a useful tool for the study of early, nonproliferative stage of the DR. However, at this time no animalmodel has yet been found to reproduce the vascular andnon-vascular complications associated with advancedstages of the disease. In this review, we show the advantagesand disadvantages of these models and we also provideinformation for planning experimental studies of DR that willlead to new strategies for its prevention and treatment.