The role of low-density lipoprotein receptor-related protein 1 in lipid metabolism, glucose homeostasis and inflammation

DATO, VIRGINIA ACTIS; PAZ, MARÍA C.; REY FEDERICO E; SANCHEZ MC,; VICENTA LLORENTE-CORTES; CHIABRANDO, GUSTAVO ALBERTO; CESCHIN D

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MDPI AG

Año: 2018 vol. 19

1661-6596

etabolic syndrome (MetS) is a highly prevalent disorder which can be used to identify individuals with a higher risk for cardiovascular disease and type 2 diabetes. This metabolic syndrome is characterized by a combination of physiological, metabolic, and molecular alterations such as insulin resistance, dyslipidemia, and central obesity. The low-density lipoprotein receptor-related protein 1 (LRP1—A member of the LDL receptor family) is an endocytic and signaling receptor that is expressed in several tissues. It is involved in the clearance of chylomicron remnants from circulation, and has been demonstrated to play a key role in the lipid metabolism at the hepatic level. Recent studies have shown that LRP1 is involved in insulin receptor (IR) trafficking and intracellular signaling activity, which have an impact on the regulation of glucose homeostasis in adipocytes, muscle cells, and brain. In addition, LRP1 has the potential to inhibit or sustain inflammation in macrophages, depend