Identifying a novel functional domain within the p115 tethering factor required for Golgi ribbon assembly and membrane trafficking

GRABSKI R; BALKLAVA, Z; WYROZUMSKA, P; SZUL,T; BRANDON, E; ALVAREZ, C; HOLLOWAY, Z; SZTUL, E

COMPANY OF BIOLOGISTS LTD

Lugar: Cambridge CB4 0DL; Año: 2012 vol. 125 p. 1896 - 1896

p style="TEXT-INDENT: 36pt; MARGIN: 0cm 1.8pt 6pt 0cm; mso-pagination: none; mso-layout-grid-align: none" class="MsoNormal">The tethering factor p115 has been shown to facilitate Golgi biogenesis and membrane traffic in cells in culture. However, the role of p115 within an intact animal is largely unknown. Here, we document that RNAi-mediated depletion of p115 in the nematode C. elegans causes accumulation of the yolk protein (YP170) in body cavity and the retention of the yolk receptor RME-2 in the ER and the Golgi within oocytes.