CREB3L2 Modulates Nerve Growth Factor-Induced Cell Differentiation

SAMPIERI, LUCIANA; FUNES CHABÁN, MACARENA; DI GIUSTO, PABLO; ROZÉS-SALVADOR, VICTORIA; ALVAREZ, CECILIA

Frontiers in Molecular Neuroscience

Frontiers Media S.A.

Lugar: Lausane; Año: 2021 vol. 14

erve growth factor (NGF) stimulates numerous cellular physiological processes, including growth, differentiation, and survival, and maintains the phenotype of several neuronal types. Most of these NGF-induced processes require adaptation of the secretory pathway since they involve extensive remodeling of membranes and protein redistribution along newly formed neuritic processes. CREB3 transcription factors have emerged as signaling hubs for the regulation of numerous genes involved in the secretory pathway and Golgi homeostasis, integrating stimuli from multiple sources to control secretion, posttranslational modifications and trafficking of proteins. Although recent studies have focused on their role in the central nervous system, little is known about their participation in cell differentiation. Therefore, we aimed to analyze the expression and signaling mechanism of CREB3 transcription factor family members, using the NGF-induced PC12 cell differentiation model. Results show that N