ALVAREZ CECILIA INÉS
Congresos y reuniones científicas
Título:
POSTER en WORKSHOP
Autor/es:
ROZÉS-SALVADOR, VICTORIA; ALVAREZ, CECILIA
Lugar:
Santa Cruz
Reunión:
Workshop; EMBO Workshop Emerging Concepts of the Neuronal Cytoskeleton; 2023
Institución organizadora:
IUBMB EMBO
Resumen:
CREB3L1 belongs to the CREB3 family of transcription factors that are implicated in the ER and Golgi
stress responses as regulators of the cell secretory capacity and cell specific cargos. In response to
different signals, CREB3 proteins are transported from the ER to the Golgi complex where they are
cleaved (activated) by S1P and S2P proteases sequentially. Although CREB3 factors have a wide
range of biological functions, their role in neuronal development is not well understood. In our study, we
observed that CREB3L1 localizes to the basal bodies of primary cilia during early neuronal cell
development. Primary cilia are sensory organelles that project from the plasma membrane of many cell
types, including neurons. They play an important role in intracellular signaling pathways and act as
sensory organelle for extracellular and intracellular signals. Our preliminary results show that CREB3L1
colocalizes with γ-tubulin and inversin, a protein located in the basal body of primary cilia at early
culture times (3DIV). This basal body localization is lost when CREB3L1 activation by S1P and S2P proteases is inhibited. Our findings suggest that CREB3L1 may have a non-canonical function in
primary cilia that is important for neuronal development and function. Further research on this topic
could provide new insights into the mechanisms underlying neuronal function.
Funding:PICT 2019-1625 (CA), PICT 2020-00995 (VRS)
stress responses as regulators of the cell secretory capacity and cell specific cargos. In response to
different signals, CREB3 proteins are transported from the ER to the Golgi complex where they are
cleaved (activated) by S1P and S2P proteases sequentially. Although CREB3 factors have a wide
range of biological functions, their role in neuronal development is not well understood. In our study, we
observed that CREB3L1 localizes to the basal bodies of primary cilia during early neuronal cell
development. Primary cilia are sensory organelles that project from the plasma membrane of many cell
types, including neurons. They play an important role in intracellular signaling pathways and act as
sensory organelle for extracellular and intracellular signals. Our preliminary results show that CREB3L1
colocalizes with γ-tubulin and inversin, a protein located in the basal body of primary cilia at early
culture times (3DIV). This basal body localization is lost when CREB3L1 activation by S1P and S2P proteases is inhibited. Our findings suggest that CREB3L1 may have a non-canonical function in
primary cilia that is important for neuronal development and function. Further research on this topic
could provide new insights into the mechanisms underlying neuronal function.
Funding:PICT 2019-1625 (CA), PICT 2020-00995 (VRS)
