Activation of TLR4 on tumor cells in vitro inhibits further tumor growth in vivo

VIRGINIA ANDREANI, GERARDO GATTI, LUCIO SIMONELLA, VIRGINIA RIVERO AND M MACCIONI

CANCER RESEARCH

Año: 2007 p. 10519 - 10519

0008-5472

p class="MsoBodyText2" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%; TEXT-ALIGN: justify">Whereas an eruption of information regarding the role of Toll like receptor 4 (TLR4), the main receptor for bacterial lipopolysaccharide, in activating macrophages and dendritic cells has emerged, very little is known about the role of TLR4 present on epithelial cells from sterile environments, like tumors. The main goal of this work was to investigate the consequences of TLR4 activation present on tumor cells in two different animal models of cancer: the Dunning rat prostate cancer and the B16 murine melanoma models. We demonstrate that a) activating TLR4 signaling in two different t