Improved antibiofilm activity of Ciprofloxacin loaded in Eudragit E100 aqueous dispersions against Fluoroquinolone-resistant Pseudomonas aeruginosa.

ALOVERO, FABIANA L.

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Lugar: Buenos Aires; Año: 2017 vol. 77 p. 559 - 559

0025-7680

ising antibiotic resistance and declining development and approval of new drugs motivates approaches to increase the efficacy of existing antibiotics. Previously we reported that fluoroquinolones-containing Eudragit E100 aqueous dispersions exhibit enhanced bactericidal effect against multidrug-resistant P.aeruginosa in planktonic state. However, P.aeruginosa is an opportunistic pathogen with ability to form biofilms, which are inherently resistant to both antimicrobial agents and host defenses, causing serious problems in the chemical, medical and pharmaceutical industries. Therefore, there is a significant need to develop alternatives to prevent biofilm formation and, more importantly, to disperse or eradicate preattached biofilms. The aim of this work was to evaluate the effect of Ciprofloxacin-containing Eudragit E100 aqueous dispersions (EuCl-CIP) on biofilms of P.aeruginosa formed in Mueller-Hinton broth with standardized bacterial inoculum (106 CFU/mL) and incubated at 37oC for