In vitro pharmacodynamic properties of a fluoroquinolone pharmaceutical derivative: hydrochloride of ciprofloxacin-aluminum complex.

FABIANA L. ALOVERO Ó F. L. ALOVERO; MARIA E, OLIVERA; RUBEN HILARIO, MANZO

ELSEVIER SCIENCE BV

Año: 2003 vol. 21 p. 446 - 446

ome in vitro pharmacodynamic properties of a new aqueous soluble ciprofloxacin CIPX) derivative, the hydrochloride of its aluminium complex: (HCl · CIPX)3 Al, are reported. Although (HCl · CIPX)3 Al had the same MIC as CIPX, the minimum bactericidal activity against Escherichia coli was 2-fold higher than that of CIPX and the rate of killing was slightly delayed compared with time-kill curves obtained with CIPX. (HCl · CIPX)3Al showed a longer post-antibiotic effect (PAE). As pharmacodynamic properties of CIPX are not drastically affected by being complexed with aluminium, the increased aqueous compatibility of the complex remains as the main formulation factor for liquid dosage forms.