THE EFFICACY OF VANCOMYCIN AGAINST Staphylococcus aureus IS ENHANCED BY THE ACTION OF A CATIONIC POLYMER

ALOVERO, FABIANA L.

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Lugar: Buenos Aires; Año: 2019 vol. 79 p. 64 - 64

0025-7680

eports of occurrence of methicillin-resistant S.aureus (MRSA) strains with resistance to the few available drugs such as vancomycin (VAN), daptomycin, linezolid, tigecycline and teicoplanin, prompt the search for novel treatments options.The last decade has witnessed enormous research focused on cationic polymers for various alternative therapeutic applications. We have previously used EudragitE100 (Eu), a cationic polymer, as a carrier of ionizable drugs which exhibited changes in their physicochemical or biological properties. The antimicrobial efficacy of Eu-VAN (VAN-containing Eu aqueous dispersions) against MRSA was evaluated and studies were conducted to understand the mechanisms involved in the observed effects.Eu-VAN bactericidal activity was evaluated by killing curves. VAN and free-drug Eu were assayed for comparison purposes. Eu-VAN at 4xMIC of VAN caused 99.9% killing within 360 min and bacterial erradication was observed within 24 h, whereas VAN needed 4-fold higher conce