Inhibitory Receptor Expression on T Cells as a Marker of Disease Activity and Target to Regulate Effector Cellular Responses in Rheumatoid Arthritis

ACOSTA, CRISTINA

Arthritis & Rheumatology

Wiley

Año: 2018 vol. 70 p. 1429 - 1429

bjective: Inhibitory receptors (IRs) are essential to regulate effector immune responses and may play critical roles during autoimmune diseases. In RA, we evaluated whether IR expression on T cells showed correlation to immune activation, disease activity and response to treatment as well as if inhibitory pathways are operative. Methods: By flow cytometry we performed extensive phenotypic and functional evaluation of CD4+ and CD8+ T cells from blood and synovial fluid of RA patients both ex vivo and after culture. All the parameters were correlated with disease activity score (DAS28) and response to treatment. Results: IRs expression showed an inverse relationship with DAS28 but no correlation with activation in RA patients with low T cell activation (CD69+CD8+ T cells