ACOSTA CRISTINA DEL VALLE
Artículos
Título:
Tofacitinib treatment of Rheumatoid Arthritis: Increases senescent T-cell frequency in patients and limits T-cell function in vitro
Autor/es:
CRISTINA DEL VALLE ACOSTA
Revista:
EUROPEAN JOURNAL OF IMMUNOLOGY
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Lugar: Weinheim; Año: 2023
ISSN:
0014-2980
Resumen:
nraveling the immune signatures in rheumatoid arthritis (RA) patients receiving varioustreatment regimens can aid in comprehending the immune mechanisms? role in treatmentefficacy and side effects. Given the critical role of cellular immunity in RA pathogenesis,we sought to identify T-cell profiles characterizing RA patients under specific treatments.We compared 75 immunophenotypic and biochemical variables in healthy donors(HD) and RA patients, including those receiving different treatments as well as treatmentfreepatients. Additionally, we conducted in vitro experiments to evaluate the direct effectof tofacitinib on purified naïve and memory CD4+ and CD8+ T cells. Multivariate analysisrevealed that tofacitinib-treated patients segregated from HD at the expense of T-cellactivation, differentiation, and effector function-related variables. Additionally, tofacitinibled to an accumulation of peripheral senescent memory CD4+ and CD8+ T cells. In vitro,tofacitinib impaired the activation,
