Mechanism of the water reaction in ester hydrolysis

MARIANA ADELA FERNÁNDEZ; RITA HOYOS DE ROSSI

Universidad Federal de Santa Catarina

Lugar: Florianópolis; Año: 1998 vol. 4 p. 450 - 450

p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal">The kinetics of the hydrolysis of compounds 1 and 2 were studied as a function of pH and buffer concentration. The reactions are general base catalyzed and gave linear Bronsted plots. The rate of the reaction increases, as the leaving group becomes better. Based on beta leaving groups values and cross correlations beta-pK we suggest that the reaction mechanism involve general base catalyzed addition of water to the carbonyl group and that the observed rate constant has participation on the leaving group departure.