Cyclodextrin modified niosomes to encapsulate hydrophilic compounds

NOELIA MACHADO; O.FERNANDO SILVA; RITA HOYOS DE ROSSI; MARIANA A. FERNÁNDEZ

RSC Advances

Royal Society of Chemistry

Año: 2018 vol. 8 p. 29909 - 29909

2046-2069

iosomes were prepared from equimolar mixtures of two non-ionic surfactants, Span 80 and Tween 80.The capability of the vesicular systems was studied through the encapsulation of two azo dyes asmolecular probes of different hydrophobicity (methyl orange (MO) and methyl yellow (MY)). To improvethe efficiency of the niosomes to encapsulate the dyes, we employed an additional modification of thevesicular system, adding b-cyclodextrin (b-CD) or a modified amphiphilic b-CD (Mod-b-CD) to theniosomes. Neither the inclusion of dyes nor the incorporation of b-CD to the niosomes producesconsiderable modifications in size and morphology of the vesicles. However, in the presence of Mod-b-CD the niosomes became smaller, probably due to the anchoring of the cyclodextrin at the surface ofvesicles through the hydrophobic chain, altering the curvature of the outer monolayer and reducing thesurface charge of the interphase. The entrapment efficiency (EE) for MY was higher than that for MO inniosomes wit