Micelle to vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity

ERICA MARCELA PACHÓN GÓMEZ; O. FERNANDO SILVA; MARTÍN DER OHANNESIAN; MARIANA NÚÑEZ FERNÁNDEZ; RAFAEL G. OLIVEIRA; MARIANA A. FERNÁNDEZ

JOURNAL OF MOLECULAR LIQUIDS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2022 vol. 353 p. 118793 - 118793

0167-7322

emini surfactants are amphiphilic molecules formed by two polar heads and twohydrophobic tails joined by a spacer between the polar groups. Their molecular structuregives them particular physico-chemical properties in comparison with their monomericcounterparts. In this work we synthetized a Gemini surfactant (SDDC) derived from theamino acid cystine and decanoic acid. The influence of different metallic salts on theaggregation of the surfactant was studied. SDDC forms core-shell type triaxial ellipsoidalmicelles in aqueous solution, but the aggregates suffer a change in morphology, formingvesicles in the presence of copper or silver ions. This behavior was corroborated by TEMand SAXS measurements. With the last technique was possible to estimate that vesiclesformed in presence of copper consisted of 7.3 stacked bilayers. It was possible todetermine that Cu2+ was reduced to Cu+ in the solution containing SDDC, through EPRand UV-visible spectrophotometry measurements. The reduction of