Cholesterol free niosome production by microfluidics: comparative with other conventional methods

NOELIA MACHADO; PABLO GARCÍA MANRIQUE; MARIANA A. FERNÁNDEZ; MARÍA CARMEN BLANCO-LÓPEZ; MARÍA MATOS; GEMMA GUTIÉRREZ

CHEMICAL ENGINEERING RESEARCH & DESIGN

INST CHEMICAL ENGINEERS

Año: 2020 vol. 162 p. 162 - 162

0263-8762

he extended use of niosomes in food, cosmetic and pharmaceutical industries demands novel preparation processes which could enhance nanovesicles production with controlled size and size distribution. Microfluidics (MF) are a novel promising set of preparation methods for this purpose. Previous studies focused on the comparison of the different preparation methods regarding niosomes are limited.In this work, niosomes using MF were produced and the effect of membrane compounds concentration and the relation between organic and aqueous ratio (flow rate ratio, FRR) on the resulting mean size and size distribution were studied. Two different cholesterol free formulations were tested using Tween® 80 and Span® 80 in presence and absence of 1-dodecanol as membrane stabilizer. The effect of FRR showed to be the key parameter in niosomes production, being more critical than membrane compounds concentration and the vesicle membrane composition.Additionally, the same formulations were also produc