Neuroprotective Effects of Resveratrol in Ischemic Brain Injury

NOELIA D. MACHADO; GORKA VILLENA ARMAS; MARIANA A. FERNÁNDEZ; SANTIAGO GRIJALVO; DAVID DÍAZ DÍAZ

NeuroSci

MDPI

Lugar: Basel; Año: 2021 vol. 2 p. 305 - 305

Cerebral ischemia represents the third cause of death and the first cause of disability inadults. This process results from decreasing cerebral blood flow levels as a result of the occlusionof a major cerebral artery. This restriction in blood supply generates low levels of oxygen andglucose, which leads to a decrease in the energy metabolism of the cell, producing inflammation, andfinally, neurological deterioration. Currently, blood restoration of flow is the only effective approachas a therapy in terms of ischemic stroke. However, a significant number of patients still have apoor prognosis, probably owing to the increase in the generation of reactive oxygen species (ROS)during the reperfusion of damaged tissue. Oxidative stress and inflammation can be avoided bymodulating mitochondrial function and have been identified as potential targets for the treatmentof cerebral ischemia. In recent years, the beneficial actions of flavonoids and polyphenols againstcerebrovascular diseases ha