Design of chitosan mucoadhesive devices for bucal drug delivery

AGUSTINA ALDANA; AGUSTIN GONZALEZ; MIRIAM C. STRUMIA; MARISA MARTINELLI

ELSEVIER SCIENCE SA

Año: 2012 vol. 134 p. 317 - 317

he study of the physicochemical and functional properties of chitosan films cross-linked with genipinand poly(N-vinyl-2-pyrrolidone) (PVP) was performed in this work. Cross-linked films were prepared bycasting method from acetic acid solutions. The structure and physical properties of the films were analyzedby infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (13C NMR), differentialscanning calorimetry (DSC) and mechanical testings. Propranolol hydrochloride was used like a modeldrug to determine the behavior of drug release from films. The drug release capacity was measured andcompared with the degree of cross-linking, mechanical properties and swelling index.There was an appropriate balance of hydrophilicity, mechanical properties and diffusion by the incorporationof PVP into the networks cross-linked with genipin. The combination of both cross-linkers allowsobtaining a soft and tough material potentially app