Formation and characterization of Langmuir and Langmuir-Blodgett films of Newkome-type dendrons in presence and absence of a therapeutic compound, for the development of surface mediated drug delivery systems

NAHIR DIB; ANA LUCIA REVIGLIO; LUCIANA FERNANDEZ; GUSTAVO MORALES; MARISA SANTO; LUIS OTTERO; FABRISIO ALUSTIZA; ANA CECILIA LIAUDAT; PABLO BOSCH; MARCELO CALDERÓN; MARISA MARTINELLI; MIRIAM C. STRUMIA

JOURNAL OF COLLOID AND INTERFACE SCIENCE

ACADEMIC PRESS INC ELSEVIER SCIENCE

Lugar: Amsterdam; Año: 2017

0021-9797

rganic macromolecules with dendrimeric architectures are polymeric materials potentially useful asnanocarriers for therapeutic drugs. In this work, we evaluate a series of Newkome-type dendrons inLangmuir and Langmuir-Blodgett films as platforms capable of interacting with a potential antitumoralagent. The nanocomposite is proposed as model for the development of surface mediated drug deliverysystems. We were successful in the formation and characterization of pure (dendrons) and composite(drug-dendron) stable and reproducible monolayers, and their transfer to solid substrates. A detailedstudy of topographic characteristics of the generated surfaces by atomic force microscopy was conducted.Furthermore, we probed dendron monolayer films as anchorage surfaces for mammalian cells. Normalcell attachment and proliferation on the surfaces were observed. No evident cytotoxic effects weredetected, demonstrating the adequate biocompatibility of the surfaces.