Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes

MONICA GARCIA; MARISA MARTINELLI; NICOLAS PONCE; LILIANA SANMARCO; MARIA PILAR AOKI; RUBEN MANZO; ALVARO JIMENEZ KAIRUZ

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2018 vol. 120 p. 107 - 107

0928-0987

nterpolyelectrolyte complexes (IPEC) formulated as multiparticulate drug delivery systems (MDDS) are interestingcarriers to improve drug? performance. Benznidazole (BZ) is the first?line drug for Chagas treatment;however, it presents side effects and toxicity, conditioning its efficacy and safety. The goal of this work was toobtain novel MDDS composed by IPEC based on different polymethacrylate carriers loaded with BZ and toinvestigate in vitro drug delivery performance for oral administration. Physicochemical characterizations werestudied and preclinical studies in a murine model of acute Chagas disease were also performed. The MDDScomposed by BZ-loaded IPEC based on polymethacrylates were obtained by casting solvent followed by wetgranulation methods with yields > 83%. FT-IR demonstrated ionic interaction between the polyelectrolytes.Confocal microscopy, DSC and PXRD revealed a fraction uniformly distributed of free BZ on the multiparticles.The rheological evaluation of the MDDS sho