Preparation and characterization of dendronized chitosan/gelatin-based nanogels

ROSSO, ANABELLA P.; MARTINELLI, MARISA

EUROPEAN POLYMER JOURNAL

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2020 vol. 124

0014-3057

he composition, functionality and morphological structure of biomaterials control their properties, such as the hydrophilic/hydrophobic character, the magnitude of the inter/intramolecular interaction, and architecture and size, which determine their potential applications. The adequate combination of nanoscale with natural polymers could then yield nanogels (NGs) with greater relevance for biomedicine. Also, the dendritic structures can be combined with NGs to improve their applications. Then, the dendronized NGs combine the advantages of hydrogels, the nanoscale and multifunctionality, generating composite materials with synergic properties.Dendronized natural polymer-based NGs were prepared by inverse nanoemulsion. Gelatin and chitosan were crosslinked with 0.3, 0.6 and 0.9 wt% of tannic acid, and dendronized with weisisocyanate dendron. The NGs were characterized using infrared microscopy, thermogravimetric analysis and dynamic light scattering. IR spectra and thermic analysis all