Huperzia saururus increases memory retention in rats

VALLEJO, , M.,; M., ORTEGA; CABRERA J.L.; CARLINI V.,; RUBIALES DE BARIOGLIO S; AGNESE M.

Elsevier

Año: 2007 p. 685 - 685

i> Huperzia saururus is reported in Argentinean popular medicine as a memory improver. Chemical studies have shown that the main constituents of the species are Lycopodium alkaloids. On the basis of this information, a purified alkaloid extract was obtained by alkaline extraction of the aerial parts. The aim of this work was to investigate the effects of intra-hippocampal administration of the purified alkaloid extract (AE) on memory retention in vivo, using a step down test, in order to correlate with previous results obtained in vitro in an electrophysiological model. The AE administration significantly increased the late