Sauroine, an Alkaloid from Huperzia saururus with Activity in Wistar Rats in Electrophysiological and Behavioral Assays related to Memory Retention.

MARIANA G. VALLEJO; MARÍA G. ORTEGA,; JOSÉ L. CABRERA; VALERIA P. CARLINI,; SUSANA RUBIALES DE BARIOGLIO; ROMINA S. ALMIRÓN, ,; OSCAR A. RAMÍREZ; ALICIA AGNESE

ACS Publications

Año: 2009 vol. 72 p. 156 - 156

font size="1"> The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus,