A prenylated flavonoid from Dalea elegans inhibits rhodamine 6G efflux in multidrugresistant Candida albicans.

MARIANA PERALTA; MAXIMILIANO CALISE; M. CECILIA FORNARI; MARIA G. ORTEGA; ROBERTO DIEZ; CABRERA J.L; P¨¦REZ C.

GEORG THIEME VERLAG KG

Año: 2012 vol. 78 p. 1 - 1

revious studies, 2′,4′-dihydroxy-5′-(1′′′,1′′′-dimethylallyl)-6-prenylpinocembrin, a prenylated flavonoid isolated from Dalea elegans roots, showed activity against multiresistant Staphylococcus aureus and Candida albicans, as well as an uncoupling effect on mitochondria and antioxidant activity. The aim of this study was to evaluate the inhibitory effects of 2′,4′-dihydroxy-5′-(1′′′,1′′′-dimethylallyl)-6-prenylpinocembrin and fluconazole on the efflux of rhodamine 6 G in azole-resistant C. albicans 12?99 that expresses multidrug transporters Cdr1p, Cdr2p, and Mdr1p. The effect of fluconazole and 2′,4′-dihydroxy-5′-(1′′′,1′′′-dimethylallyl)-6-prenylpinocembrin on rhodamine 6 G efflux was assessed in both azolesensitive and azole-resistant C. albicans. Between 1 and 1000 μM, 2′,4′-dihydroxy-5′-(1