PRENYLATED FLAVONOIDS FROM DALEA GENUS AS XANTHINE OXIDASE INHIBITORS: BIOACTIVITY EVALUATION IN VITRO AND MOLECULAR DOCKING STUDIES

M DANIELA SANTI; EINY BEDOYA; MELISA FABIANA NEGRO; MARGOT PAULINO ZUNINI; MARIANA PERALTA; M. GABRIELA ORTEGA

Results in Chemistry

Elsevier

Lugar: Dublin; Año: 2023

2211-7156

renylated flavanones are a family of compounds with an important biological potential. Previously, anti- tyrosinase activity, acetylcholinesterase inhibitory activity, and neuroprotective effects of several prenyl flavanones isolated from different American Dalea genus species were reported. The biological potency of these kinds of compounds, together with the particularity of their chemical structures, encouraged us to investigate them for in vitro and in silico anti-xanthine oxidase activity. So, five prenyl-flavanones obtained from different Dalea sp (Dalea elegans, Dalea boliviana, and Dalea pazensis) were studied and the relationships between the structure of these prenyl-flavanones and their inhibitory activity were evaluated. Molecular docking studies were performed in order to propose the binding mode of the most active natural compound. 2′,4′-dihydroxy-5′-(1‴,1‴-dimethylallyl)-8-prenylpinocembrin (1) was the most active in this series showing an