Oral treatment with Berberine reduces peripheral nociception: Possible interaction with different nociceptive pathways activated by different allogeneic substances

DEL GAUDIO, MICAELA PAULA; KRAUS, SCHEILA IRIA; MELZER, THAYZA MARTINS; BUSTOS PAMELA; ORTEGA, MARÍA GABRIELA

JOURNAL OF ETHNOPHARMACOLOGY

ELSEVIER IRELAND LTD

Año: 2024 vol. 321

0378-8741

thnopharmacological relevance: Berberine was identified in extracts of Berberis ruscifolia Lam., a plant used in traditional medicine as an analgesic. Its presence may be involved in the reported pharmacological activity of this species. However, there is still a lack of scientific research concerning its analgesic activity in the peripheral nervous system. Aim of the study: To investigate Berb-induced antinociception in the formalin test and to evaluate several pathways related to its pharmacological antinociceptive effects in chemical models of nociception in mice. Materials and methods: The antinociceptive activity of Berb was assessed by inducing the paw licking in mice with different allodynic agents. In the formalin test, the antiedematous and antithermal effect of Berb was evaluated simultaneously in the same experiment. Other nociceptive behavior produced by endogenous [prostaglandin E2 (PGE2), histamine (His), glutamate (Glu) or bradykinin (BK)] or exogenous [capsaicin (Caps)