Alzheimer?s disease (AD) is a neurodegenerative and progressive disease, caused by a dysfunction of cholinergic neurotransmission in the brain, which contributes to a salient cognitive decline, major characteristic for AD1. One of the most accepted strategies in AD treatment is the use of cholinesterase inhibitors. Their clinical efficacy is thought to result from prolonging the half-life of acetylcholine through inhibition of acetylcholinesterase (AChE)2. Several plants of the Lycopodium and Huperzia genus are reported to be active in AChE inhibition3,4. As part of our continuing studies into discovery of new cholinesterase inhibitors from Lycopodiaceae5, we report here the results of chemical and pharmacological studies performed for 2 species collected in the province