"Phototoxic effects by Heterophyllaea pustulata"

S.C. NÚÑEZ MONTOYA, L.R. COMINI, B. RUMIE VITTAR, I. M. FERNÁNDEZ, V. RIVAROLA, J.L. CABRERA

Elsevier

Año: 2008 vol. 51 p. 1409 - 1409

p style="TEXT-ALIGN: justify; MARGIN: 0cm 0cm 0pt 35.45pt" class="MsoNormal">Abstract: Heterophyllaea pustulata (Rubiaceae), a South American genus, is a phototoxic shrub that grows in the Andean mountain range of the Northwest of Argentina, popularly known as ?cegadera?. Animals that ingest the aerial parts of this plant suffer a typical primary photosensitization reaction, clinically revealed by dermatitis and blindness in severe cases. Anthraquinone derivatives (AQs), the main metabolites of this species, are characterized as Type I and/or Type II photosensitizers according to their physicochemical properties. The natural toxicity conditions were reproduced in vivo assays by