"Characterizing some photophysical, photochemical and photobiological properties of photosensitizing anthraquinones"

L.R. COMINI, S.C. NÚÑEZ MONTOYA, M. SARMIENTO, J.L. CABRERA Y G. ARGÜELLO.

Elsevier

Año: 2007 vol. 188 p. 185 - 185

p style="TEXT-ALIGN: justify; MARGIN: 0cm 0cm 0pt 35.45pt" class="MsoNormal">Abstract: Some photophysical, photochemical and photobiological properties of nine anthraquinones (AQs) isolated from a phototoxic plant, Heterophyllaea pustulata, were studied. The photosensitized generation of superoxide anion radical (O2•−) and singlet molecular oxygen (1O2) by three of the nine AQs, namely heterophylline, pustuline and 5,5´-bisoranjidiol was evaluated. Whereas the O2•− production (Type I photosensitization mechanism) was examined in vitro using human leukocyte suspensions and measuring the reduction of NBT, the 1O2 generation (Type II photosensitization mechani