"Anticoagulant effect and action mechanism of sulphated flavonoids from Flaveria bidentis"

GUGLIELMONE H.A., AGNESE A.M., NÚÑEZ MONTOYA S.C., CABRERA, J.L.

Pergamon Press IF= 1.71 (2003-Elsevier)

Año: 2002 vol. 105 p. 183 - 183

p style="TEXT-ALIGN: justify; MARGIN: 0cm 0cm 0pt 54pt; mso-list: skip" class="MsoNormal">Abstract: Quercetin 3-acetyl-7,3`,4`-trisulphate (ATS) and quercetin 3,7,3´,4´-tetrasulphate (QTS) obtained from Flaveria bidentis (Asteraceae)were investigated in vitro for anticoagulant activity. Three different concentrations of each flavonoid were assayed at different incubation times, showing at 1mM significant prolongation on the activated partial thromboplastin time (APTT), less on the prothrombin time (PT), and no effect on the thrombin time (TT). In order to define the action mechanism of the anticoagulant activity, all coagulation factors were evaluated and no important activity decrease was observed, indicating that another mechanism is involved. Thus, thrombin inhibition mediated b