"Inhibitory effects of sulphated flavonoids isolated from Flaveria bidentis on platelet aggregation"

GUGLIELMONE, H.A., AGNESE, A.M., NÚÑEZ MONTOYA, S.C., CABRERA, J.L.

Pergamon Press IF=1.71 (2003-Elsevier)

Año: 2005 vol. 115 p. 495 - 495

p style="TEXT-ALIGN: justify; MARGIN: 0cm -0.05pt 0pt 49.65pt" class="MsoNormal">Abstract: Flaveria bidentis is a plant species that has as major constituents sulphated flavonoids in the highest degree of sulphatation. Among them, quercetin 3,7,3’,4’-tetrasulphate (QTS) and quercetin 3-acetyl-7,3’,4’-trisulphate (ATS) are the most important constituents. Both showed anticoagulant properties. The objective of the present study was to evaluate the effects of these flavonoids on human platelet aggregation in comparison with the well-known inhibitor quercetin (Qc) by using several agonists. Platelet-rich plasma (PRP) or washed human platelets (WP) were incubated with different concentrations of the flavonoids to be tested (1 to 1000 AM, final concentration), and the platel