Towards effective natural anthraquinones to mediate antimicrobial photodynamic therapy of cutaneous leishmaniasis

DIMMER, JESICA A.; CABRAL, FERNANDA V.; NÚÑEZ MONTOYA, SUSANA C.; RIBEIRO, MARTHA S.

Photodiagnosis Photodynamic Therapy

ELSEVIER SCIENCE BV

Año: 2023 vol. 42

1572-1000

ackground: Cutaneous leishmaniasis (CL) is an important tropical neglected disease with broad geographical dispersion. The lack of effective drugs has raised an urgent need to improve CL treatment, and antimicrobial photodynamic therapy (APDT) has been investigated as a new strategy to face it with positive outcomes. Natural compounds have emerged as promising photosensitizers (PSs), but their use in vivo remains unexplored. Purpose: In this work, we investigated the potential of three natural anthraquinones (AQs) on CL induced by Leishmania amazonensis in BALB/c mice. Study Design/Methods:: Animals were infected and randomly divided into four groups: CG (control, non-treated group), G5ClSor-gL (treated with 5-chlorosoranjidiol and green LED, 520±10 nm), GSor-bL and GBisor-bL (treated with soranjidiol and bisoranjidiol, respectively, exposed to violet-blue LED, 410±10 nm). All AQs were assayed at 10 μM and LEDs delivered a radiant exposure of 45 J/cm2 with an irradiance of 50 mW/