Rubiadin: A natural photosensitizing anthraquinone with antifungal activity in vitro

J MARIONI, ML MUGAS, JL CABRERA, SC NÚÑEZ MONTOYA; JE ARCE MIRANDA, MG PARAJE

Córdoba

Congreso; 16th INTERNATIONAL CONGRESS ON PHOTOBIOLOGY; 2014

IUPB, Facultad Ciencias Químicas, UNC

Extracts rich in anthraquinones (AQs) of Heterophyllaea pustulata Hook. f. (Rubiaceae), have shown in vitro antifungal effect against planktonic microorganisms. We have established that their purified AQs exhibit photosensitizing activity type I and/or II[1]. Since the most important group of opportunistic fungal pathogens are Candida species[2], in this study we evaluate the antifungal activity of Rubiadina (RUB), one of the majority AQs from these extracts, against different Candida strains, analyzing whether this effect could be increased by irradiation.