Phototherapeutic Study of Rubiadin: Photosensitizing Anthraquinone Isolated from Heterophyllaea pustulata (Rubiaceae)

COMINI LR, NÚÑEZ MONTOYA SC, CABRERA JL.; FERNÁNDEZ I, RUMIE VITTAR B, RIVAROLA V.

Córdoba

Congreso; 16th INTERNATIONAL CONGRESS ON PHOTOBIOLOGY; 2014

IUPB, Facultad Ciencias Químicas, UNC

Rubiadin is an anthraquinone isolated from the phototoxic shrub, Heterophyllaea pustulata Hook f. We demonstrated that this AQ is photosensitizer Type I and Type II. Considering that an important research line, studies photosensitizing compounds and their uses in photodynamic therapy (PDT), the photodynamic activity of Rubiadin in vitro was evaluated with satisfactory results. The next step was to evaluate their photodynamic activity in vivo, which is the aim of this work. Therefore, the pharmacokinetic, acute toxicity and phototherapeutic studies were assayed in a Balb/C mouse cancer model.